Abstract: Objective To explore the relationship between ACE gene polymorphism and intracranial aneurysms.Methods To compare the allele gene and genotype frequency of this insertion and deletion polymorphism in the 16 intron of ACE gene in 87 patients with intracranial saccular aneurysms (aneurysm group) and 108 healthy volunteers (control group) by means of polymerase chain reaction (PCR), agarose gel electrophoresis and direct sequencing.Results The frequency of insertion and deletion genotype ( I/D ) in aneurysm group was significantly higher than that in control group( P =0.008); The frequency of deletion genotype (D/D) in aneurysm group was significantly lower than that in control group( P =0.04).Conclusion The ACE gene insertion and deletion (I/D)and deletion (D/D)polymorphism in the locus of 16 intron in Hans may be correlated with the pathogenesis of intracranial aneurysms.

Key words: angiotensin converting enzyme, polymorphism of gene, intracranial aneurysm