Abstract:

Objective To analyze the clinical features of 16 cases with T1DM and AIDT and to evalute the effect of AITD on T1DM.Methods General data of 16 cases were analyzed including family history,physical signs, hormones and antibodies.T test was used to compare the insulin and HbA_1C between 2 groups.Results The onset age of the patients was 7～14 years old,median age was 10.56.3 cases were male and 13 female,The interval between two diseases onset was 0～10 years.T1DM combinded with GD or HT were 4 and 12 cases,respectively.4 patients had family history.The levels of HbA_1C of GD were 10%,12% and 14%,respectively before alleviation;GD combinded with hyperparathyroidism were 11.8% and 10.2%,GD combinded with hypoparathyroidism was 6.3%～10%.There were significantly difference between the two groups above metion(P=0.003).Conclusion There are more famales than males,more HT than GD in APS.Most of APS have family history.It is imporfant to check the thyroid function and antibodies early and regularly for T1DM patients,especially for girls.

Key words: auto-immune poly-glandular syndrome, type 1 diabetes, autoimmune thyroid disease, Graves disease, Hashimoto(disease)