Abstract: Objective To investigate the incidence of adverse effects of propofol in large samples and multi-center epidemiological study.Methods The patients without premedication were induced with propofol at 0.2 mL/s with peripheral venous injection.The pain evaluation was performed every 5～100s and restlessness and talkative were investigated until the patients losing consciousness.Results 10 680 questionnaires that recorded pain scale were received.The incidence of mild injection pain was 36.25%,moderate pain was(3.19)%,and severity pain was 0.66%.The total incidence of injection pain was 40.09%.The incidences of pain were not significantly different between male and female((P=0.124)),or between venous injection from upper limb and lower limb(P=0.468).7 815 questionnaires that surveyed restlessness and 7 192 questionnaires that surveyed talkative were received.The number of patients' occurrence restlessness and talkative were 716 and 168,respectively.The incidence of restlessness and talkative was 9.2% and(2.3)%,respectively.Conclusion Injection pain is the most common adverse.The incidence of injection pain of propofol 1% fresenius injection was 40.09%.Some measures should be taken to prevent the injection pain.

Key words: propofol, side effect, injection, pain