Abstract: Parkinson disease is a kind of neurodegenerative disease.The classic pathological finding of Parkinson disease is Lewy body(LB).Certain genic mutation would induce Parkinson disease,such as α-synuclein,Parkin,UCHL1 which are ascertained to be associated to Parkinson disease.These gene mutants damage the ubiquitin-proteasomes system(UPS),the UPS dysfunction would lead to Parkinson disease.This review discasses the relation between the three gene mutant ation and the ubiquitin-proteasomes system.