Immunohistochemistry Researches of Pulpal Nerve Pain Response to Stimulation of Direct Resin Composite Filling

Abstract

Abstract: Objective To evaluate the long term pulpal pain response in terms of time-sequenced changes to the stimulation of composite filling.Methods Immunohistochemistry method was used to stain the substance P(SP) in pulpal tissue which could directly reflect the activation of nerve by stimuli.Results In the area of odontoblast and their protrusions, the SP-immunoreactive nerve fibers were stained, the grayscales of the groups which on day 1, 3, 5 after composite filling was significantly higher than control group (P<0.05), and there was no significant difference between control group and the experimental group on day 12 after composite filling(P>0.05).Conclusion The results show that the pain response induced by deep cavity composite filling may last for several days with peak response on day 1 to 3 and may alleviate as time pass-by.

Key words: composite filling, pulp, pain, substance P, immunohistochemistry

CLC Number:

R781.3

Chen Su;Xie Jianyun;Li Jingjin. Immunohistochemistry Researches of Pulpal Nerve Pain Response to Stimulation of Direct Resin Composite Filling[J]. Journal of Capital Medical University, 2006, 27(3): 298-301.

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Immunohistochemistry Researches of Pulpal Nerve Pain Response to Stimulation of Direct Resin Composite Filling

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