Abstract: Objective To detect the existent form of mercury and arsenium in Angong Niuhuang Wan(ANW) and the absorption and excreting in rats.Methods The existent form of mercury was detected with high performance capillary electrophoresis.Mercury and arsenium of vermilion and realgar in artificial gastric and intestinal juice,and mercury and arsenium excreted out of rats fed with mercuric sulfide,arsenic disulfide and ANW were respectively tested with cold vapour-atomic absorption spectrometry and hydrogen arsenide based method.Results Mercury scutellarin was detected.Mercury of vermilion in artificial gastric and intestinal juice respectively was 0.003 05% and 0.000 04%.Arsenium in those Mercury and arsenium of vermilion and realgar were respectively was 0.033 75% and(0.000 61%).24 h later,more than 90.195 0% mercury was excreted out of rats fed with mercuric sulfide;26.437 9% arsenium was excreted out of rats fed with arsenic disulfide;82.830 9% mercury and 24.442 0% arsenium were excreted out of rats fed with ANW.The difference of excreted mercury and arsenium is not significant between rats fed with ANW and rats fed with mercuric sulfide and arsenic disulfide.Conclusion The absorption and excretion of mercury and arsenium from ANW,mercuric sulfide and arsenic disulfide in rats are analogical.

Key words: Angong Niuhuang Wan, mercury, arsenium, absorption, excreting