Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (6): 703-706.

• 专题报道 • Previous Articles     Next Articles

Identification of the Follicular Occlusion Triad Susceptibility Locus by a Genome Wide Scan

Gao Min1, Wang Peiguang1, Cui Yong1, Yang Sen1, Lin Da1, Li Hui1, Du Wenhui1, Huang Wei2, Zhang Xuejun1   

  1. 1. Institute of Dermatology & Department of Dermatology, Anhui Medical University, The Key Lab of Gene Resource Utilization for Severe Hereditary Disease, The Key Lab of Gene Resource Utilization for Severe Hereditary Disease of Ministry of Education;2. Chinese National Human Genome Center
  • Received:2006-09-26 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24

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Abstract: Objective To identify the locus for follicular occlusion triad in a four-generation Chinese family.Methods A genome-wide scan was performed with 400 microsatellite markers in a Chinese follicular occlusion triad family to map the chromosome locations of the susceptible gene.Two-point linkage analysis was performed using Linkage programs version 5.10 and haplotype was constructed with Cyrillic version 2.01.Results A locus was identified at chromosome 1p21.1-1q25.3 with a cumulative maximum two-point LOD score of 3.26 at microsatellite markers D1S2624(at recombination fraction=0.00).Haplotype analysis indicated that the candidate gene was located within 61.8 cM region between markers D1S248 and D1S2711.Conclusion Chromosome 1p21.1-1q25.3 contains the candidate gene susceptible for the follicular occlusion triad.

Key words: the follicular occlusion triad, gene mapping, linkage analysis

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