Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (6): 792-794.

• 基础研究 • Previous Articles     Next Articles

The Different Expression Levels of Human Beta Defensins in the Lung Cancer Cell Line A549 Cells after Treated with Allicin

Si Ligang1, Liu Xicheng1, Li Wenmei2, Lv Youyong2, Rao Xiaochun1, Ma Yuyan1   

  1. 1. Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital University of Medical Sciences;2. Molecular Biology Laboratory, Beijing Institute for Cancer Research, School of Oncology, Peking University
  • Received:2006-04-20 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24

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Abstract: Objective Human beta defensins(HBD) are antimicrobial peptides mainly generated by the epithelia of human body,Allicin is a antimicrobial drug made in China,our research is to investigate what might be the mechanism involved in improving the immunity of human body. Methods We used RPMI 1640 which included 5 μg/mL Allicin to culture the lung cancer cell line A549,and detected the mRNA expression levels of different kinds of HBD(HBD1～3). Results The HBD3 expression level could be improved,and there were no effects on the expression level of HBD1 and HBD2. Conclusion Allicin can improve the expression level of HBD3 in the cell line A549,that might be one of the reasons which allicin involve in the adjustment of human immunity.It further confirmed that there were different signalling pathways between HBD3 and HBD2.

Key words: human beta defensins, allicin, antimicrobial peptides, induced expression

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