Abstract: Objective To discuss the effects of lodixanol on patients with moderate to severe renal failure.Methods One hundred and twenty-six patients who had undergone coronary angiography and intervention were retrospectively analyzed.These 126 cases were divided into group A(72 cases,using lodixanol) and group B(54 cases,using iohexol).Between group A and B,the clinical features,serum creatinine(Scr),creatinine clearance rates(Ccr),and mobidity rates and prognosis of radiocontrast induced nephropathy(CIN) were compared.Results There was no difference in pre-procedure risk factors of CINbetween group A and B.In both groups there were Scr increasing and Ccr decreasing which caused CIN.However,the CIN rates were lower in group Athan in group B(4.2% vs 29.6%,P<0.05).There were 6 cases of adverse effects,5 of them were in group B.Conclusion Comparing with hypotonic contrast agents,the isotonic contrast agents could lower Scr baseline level and CINoccurrence rates,at the same time adverse effects can be reduced especially in patients with chronic renal failure or diabetes.

Key words: patients with chronic renal failure, lodixanol, contrast-induced nephropathy, adverse effects