Abstract: Hemodiafiltration(HDF) is an extracorporeal renal-replacement technique using a highly permeable membrane, in which diffusion and convection are combined to enhance solute removal in a wide spectrum of molecular weights. HDF can improve clinical conditions and reduce morbidity compared with conventional hemodialysis. In this review, it summarizes recent views about clinical aspects of HDF, the main observational studies and ongoing randomized-controlled trials.

Key words: hemodiafiltration, on-line hemodiafiltration, hemodialysis, survival rate