Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (6): 770-774.doi: 10.3969/j.issn.1006-7795.2009.06.010

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Transcriptional Circuitries of T Helper cells in Allergic Diseases

Zhang Yuan1, WANG Cheng-shuo2, ZHANG Luo1,2   

  1. 1. Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology;2. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University
  • Received:2009-09-22 Revised:1900-01-01 Online:2009-12-21 Published:2009-12-21

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Abstract:

Originally interpreted within the framework of a binary TH1/TH2 paradigm, the knowledge of the pathogenesis of allergic diseases has broadened to incorporate the contribution of T regulatory cells and the newly described proinammatory TH17 cell lineage. The commitment of peripheral T-cell clones to undergo differentiation into one of those lineages is shaped by transcriptional circuitries that center on key transcriptional regulators: T-box expressed in T cells(TH1), GATA-3(TH2), forkhead box p3(T regulatory cells), and retinoid-related orphan receptor gt/retinoid-related orphan receptor a(TH17). The aim of this review is to elaborate on the transcriptional regulation mechanism of different T-cell subsets and their functions in allergic diseases.

Key words: allergic disease, T helper cell, transcriptional pathway

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