Abstract: Objective To explore the causes of elevated fibrinogen(Fib) and factors associated with clinical features in elderly patients. Methods The clinical and laboratory data of 50 elderly patients with high Fib(high Fib group) and 45 elderly patients with normal Fib(control group) were analyzed and compared. Results As compared with the control group, the patients in the high Fib group had significantly higher activated partial thromboplastin(APTT), erythrocyte sedimentation rate(ESR), and blood platelet(PLT) while their total cholesterol(TC ) was significantly reduced. Analysis of clinical diagnosis indicated that high Fib group of elderly patients had significantly more acute severe disease and higher incidence of thrombosis than those in the control group of elderly patients. Conclusion Increased fibrinogen in elderly patients may suggest higher risks for severe acute disease and the occurrence of thrombotic disorders.

Key words: elderly, fibrinogen, clinic