Abstract: Synapses are connections between neurons, biological signals are transferred from the presynaptic membrane by the synaptic transmission to the postsynaptic membrane. Changes in the number and function of synapsis can cause changes in synaptic plasticity, thereby can affect learning and memory. Postsynaptic dense area and the close relationship between synaptic plasticity are essential for the maintenance of synaptic function properly. In this article, we make a brief overview on the research of postsynaptic dense area including its discovery and composition, participation in a major neurotransmitter in synaptic plasticity, as well as the relationship between postsynaptic dense area and the synaptic plasticity.

Key words: postsynaptic density area, plasticity, learning and memory