Expression of ACE2 in Mouse Pancreas Tissue

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (3): 359-362.

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Expression of ACE2 in Mouse Pancreas Tissue

GUO Li-min¹, WANG Xia-lian¹, LIN Shan-shan¹, Yang Jin-kui^2*

1. Department of Endocrinology, Shijingshan Hospital of Beijing; 2. Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-06-21 Published:2010-06-21
Contact: Yang Jin-kui

Abstract

Abstract:

Objective This study was designed to investigate the expression of angiotensin-converting enzyme 2(ACE2) in endocrine and exocrine tissue of mouse pancreas. Methods The expressions of ACE2 in mouse pancreas was detected by reverse transcriptase polymerase chain reaction(RT-PCR) and the expressions of ACE2 in mouse pancreas was detected by immunoelectron microscopy. Results The expression of ACE2 mRNA was detected in whole mouse pancreas and lung tissues, while ACE2 protein was detected in both endocrine tissue and exocrine tissue of mouse pancreas. Conclusion These data demonstrated a tissue specific pattern of ACE2 expression in mouse pancreas and this indicated ACE2 might be present in islet of pancreas of human. Since ACE2 works as a negative regulator of the angiotensin system, the expression of ACE2 protein in endocrine tissue of pancreas may give us more clue for the treatment of diabetes.

Key words: angiotensin converting enzyme 2, SARS-CoV, S protein, pancreas

CLC Number:

GUO Li-min;WANG Xia-lian;LIN Shan-shan;Yang Jin-kui. Expression of ACE2 in Mouse Pancreas Tissue[J]. Journal of Capital Medical University, 2010, 31(3): 359-362.

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Expression of ACE2 in Mouse Pancreas Tissue

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