Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (5): 558-562.

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Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

LI Ji-feng^1,2,3, WANG Chen^1,3*, WANG Jun^1,2,3

1. Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine; 2. Department of Physiology, School of Basic Medical Sciences, Capital Medical University; 3. Faculty of Respiratory Disease, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-10-21 Published:2010-10-21
Contact: WANG Chen

Abstract

Abstract:

As the most abundant component of coagulation system, fibrinogen not only takes part in clotting, but also works as one of acute phase proteins. Fibrinogen participates in many physiological and pathophysiological processes through modulating blood viscosity, endothelial function and promotion of smooth muscle cell proliferation and migration. It has been found that there are positive associations between the abnormal structure or function of fibrinogen induced by single nucleotide polymorphisms(SNP) in fibrinogen coding sequences and many kinds of diseases, especially thrombotic disorders. This review summarized the SNP in fibrinogen coding sequences and its relationship with diseases.

Key words: fibrinogen, single nucleotide polymorphism, deep venous thrombosis, pulmonary embolism, chronic thromboembolic pulmonary hypertension, myocardial infarction, stroke

CLC Number:

R 563
R 331

LI Ji-feng;WANG Chen;WANG Jun. Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases[J]. Journal of Capital Medical University, 2010, 31(5): 558-562.

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Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

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