Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

doi:10.3969/j.issn.1006-7795.2010.05.007

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (5): 558-562.doi: 10.3969/j.issn.1006-7795.2010.05.007

Previous Articles Next Articles

Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

LI Ji-feng^1,2,3, WANG Chen^1,3*, WANG Jun^1,2,3

1. Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine; 2. Department of Physiology, School of Basic Medical Sciences, Capital Medical University; 3. Faculty of Respiratory Disease, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-10-21 Published:2010-10-21
Contact: WANG Chen

Abstract

Abstract:

As the most abundant component of coagulation system, fibrinogen not only takes part in clotting, but also works as one of acute phase proteins. Fibrinogen participates in many physiological and pathophysiological processes through modulating blood viscosity, endothelial function and promotion of smooth muscle cell proliferation and migration. It has been found that there are positive associations between the abnormal structure or function of fibrinogen induced by single nucleotide polymorphisms(SNP) in fibrinogen coding sequences and many kinds of diseases, especially thrombotic disorders. This review summarized the SNP in fibrinogen coding sequences and its relationship with diseases.

Key words: fibrinogen, single nucleotide polymorphism, deep venous thrombosis, pulmonary embolism, chronic thromboembolic pulmonary hypertension, myocardial infarction, stroke

CLC Number:

R 563
R 331

LI Ji-feng, WANG Chen, WANG Jun. Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases[J]. Journal of Capital Medical University, 2010, 31(5): 558-562.

0
/ Save 0 / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2010.05.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2010/V31/I5/558

[1]	Stroke Prevention Project, National Health Commission, Ji Xunming. Promoting the Stroke Prevention Project, National Health Commission: current status and strategy of stroke prevention and treatment in China [J]. Journal of Capital Medical University, 2025, 46(1): 11-14.
[2]	Chu Xuehong, Shen Yingjie, Wang Yaolou, Dong Xiao, Liu Yuanyuan, Feng Yan, Jiang Miaowen, Li Ming, Ji Xunming, Wu Chuanjie. Exploring the causal relationship between extensive perivascular space burden and ischemic stroke and its subtypes and transient ischemic attack based on Mendelian randomization [J]. Journal of Capital Medical University, 2025, 46(1): 22-33.
[3]	Wang Yinping, Meng Cancan, Wu Wenjuan, Yang Zhitang. The expressions of CD62P, CD40L, and Rev-erbα after ischemic stroke on different onset times [J]. Journal of Capital Medical University, 2025, 46(1): 34-40.
[4]	Zhan Yanli, Li Yiyin, Li Ping, Sun Jingping, Huang Liangtong, Cai Xueli. Analysis of the current status and efficacy of acute ischemic stroke treatment based on hierarchical medical service network [J]. Journal of Capital Medical University, 2025, 46(1): 41-47.
[5]	Zhang Meng, Ma Yongxin, Jia Qiong , Zhang Dongwei, Zhang Xinhong, Xu Yaoming . Clinical observation on the efficacy and safety of intravenous thrombolysis in the treatment of acute mild non-disabling ischemic stroke: a single-center retrospective observational study [J]. Journal of Capital Medical University, 2025, 46(1): 56-62.
[6]	Liu Xiaomeng, Zhou Shaojuan, Shao Xiaohong, Xu Wenping, Huan Feng, Zhu Xiangyang. Current situation and four-level prevention of stroke under the collaborative management model between medical prevention and treatment in Nantong [J]. Journal of Capital Medical University, 2025, 46(1): 63-67.
[7]	Qiao Yue, Li Chuanhui, Zhao Wenbo. The current status and future directions of reperfusion therapy for acute ischemic stroke [J]. Journal of Capital Medical University, 2025, 46(1): 68-70.
[8]	Li Xingmao, Li Xiu, Wang Ting, Zhao Xin, Wang Deyang, Shang Haiyan, Zhao Yongmei, Li Sen. Effects of GLP-1 receptor agonists on cognitive function in patients with type 2 diabetes mellitus after acute ischemic stroke [J]. Journal of Capital Medical University, 2024, 45(6): 1029-1037.
[9]	Shen Tong, Li Fangfang, Fan Junfen, Luo Yumin. Correlation analysis of plasma YAP level with stroke prognostic factors and post-stroke inflammation [J]. Journal of Capital Medical University, 2024, 45(6): 1071-1078.
[10]	Gu Chaoxiong, Li Ming. Stay true to the original aspiration, forge ahead, and strive for excellence in the realm of science—Professor Ji Xunming, academician of Chinese Academy of Engineering [J]. Journal of Capital Medical University, 2024, 45(3): 375-378.
[11]	Dong Zheng, Yang Qingmiao, Guo Caixia. Effect of stress hyperglycemic ratio on poor in-hospital prognosis in patients with acute myocardial infarction [J]. Journal of Capital Medical University, 2024, 45(3): 494-500.
[12]	Ma Wei, Zhou Yifan, Jiang Huimin, Wei Huimin, Zhou Chen, Ji Xunming. Research progresses in cerebral venous sinus thrombosis animal models [J]. Journal of Capital Medical University, 2023, 44(5): 704-714.
[13]	Yang Yu, Ye Cong, Yang Chengzhi, Xu Dong. A clinical study on stroke prevention in patients with non-valvular atrial fibrillation at high bleeding risk by standalone left atrial appendage closure under total thoracoscopy [J]. Journal of Capital Medical University, 2023, 44(5): 795-802.
[14]	Hu Zhengfang, Wang Juan, Jian Minyu, Han Ruquan. ffect of intraoperative oxygen concentration on postoperative neurological function and complications in patients undergoing cerebrovascular recanalization [J]. Journal of Capital Medical University, 2023, 44(5): 865-871.
[15]	Feng Dan, Li Na, Hou Dongyan. Correlation between residual lipoprotein cholesterol and acute myocardial infarction [J]. Journal of Capital Medical University, 2023, 44(5): 872-876.

Single Nucleotide Polymorphisms in Fibrinogen Coding Sequence and Thrombotic Diseases

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles 0

Metrics

Comments