Abstract: The Traditional Chinese Medicine(TCM) theory has been continually changing for thousands of years,and it contains many different schools.The birth of new medical schools are always accompanied with those major diseases' occuring in some special historical period,which has greatly enriched the TCM theories.Among the above,the Five-organs theory is the most basic one,and the basis of all the TCM theories.Besides,it has been improved and well-established by the different schools from different times.Nowadays,the TCM is facing new historical challenges and ready to undertake the significant social responsibility which means resolving the emerging new diseases.The TCM theory is sure to be innovated.In accordance with the laws of TCM's development and the diseases' changing,the authors hasd initially completed TCM Theory Innovation System and TCM Medicines Innovation System which both provide new theoretical and technical supports during the course of solving AIDS and other major diseases.

Key words: five-organs theory, TCM theory innovation system, trational Chinese medicines innovation system, AIDS