Abstract: Objective To explore the effect of Shexiangbaoxin pills (SXBXP) on expression of renal angiotensin Ⅱ receptor(ATR) subtypes in rats with heart failure.Methods Eighty male Wistar rats were randomly divided into control group (group A, n=10) and sham operation group (group B, n=10). The heart failure model was established successfully in 35 of the rest 60 male Wistar rats. The 35 heart failure model rats were randomly divided into four group: heart failure model group (group C, n=9), medicine control group (group D, n=8), small dose of SXBXP group (group E, n=9) and large dose of SXBXP group (group F, n=9). The mRNA levels of ATR subtypes of renal cortex were measured by reverse transcription polymerase chain reaction (RT-PCR) in each group. Results Compared with group A, expression of AT₁R and AT₁R showed no significant difference in group B(P>0.05), compared with group B, expression of AT₁R was increased significantly in group C(P<0.05), expression of AT₁R was decreased significantly in group C(P<0.01). Compared with group C, expression of AT₁R was decreased significantly in group D, E and F(P<0.05), expression of AT₁R was increased significantly in group D, E and F(P<0.01). Compared with group E, expression of AT₁R was decreased significantly in group F(P<0.05). Conclusion SXBXP regulated the expression of renal ATR subtypes, including the downregulation of AT₁R and the upregulation of AT₁R in rats with heart failure, and it is also effective to protect renal function and improve heart failure, especially large dose of SXBXP.

Key words: Shexiangbaoxin pills, angiotensin Ⅱ receptor, kidney, heart failure