Microalbuminuria on predicting end-stage renal disease in patients with type 2 diabetes

doi:10.3969/j.issn.1006-7795.2014.01.014

Abstract

Abstract:

Objective To analyze the value of microalbuminuria (MAU) on predicting end stage renal disease (ESRD) in patients with type 2 diabetes. Methods A total of 367 patients with type 2 diabetes were enrolled in this study. We analyzed clinical data, biochemical parameters, urinary albumin excretion rates (UAER) and estimated glomerular filtration rates (eGFR). According to the levels of UAER, the patients were divided into normal albuminuria (NAU) group and the MAU group. During an average of 5.2 years of follow-up, each time we measured the above parameters, including biochemical markers, UAER and eGFR. Results In NAU group, eGFR declined by 4.18% each year, with a total of 5.65% ESRD endpoint. In the MAU group, eGFR declined by 4.95% each year, with a total occurrence rate of ESRD of 14.29%. However, based on the survival analysis, no significant difference was found in the risk for ESRD. Based on the outcome of eGFR, all patients were divided into two groups: the renal function remaining group and ESRD group. Based on the Cox regression analysis, diastolic blood pressure was shown to be an independent risk factor for ESRD. Conclusion MAU cannot accurately predict the ESRD in patients with type 2 diabetes.

Key words: type 2 diabetes mellitus, microalbuminuria, urinary albumin excretory rate, end stage renal disease, estimated glomerular filtration rate, predicting

CLC Number:

R587.1

Guo Jing, Yang Jinkui. Microalbuminuria on predicting end-stage renal disease in patients with type 2 diabetes[J]. Journal of Capital Medical University, 2014, 35(1): 60-66.

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