Clinical features and difficulties in diagnosis of multiple sclerosis in China

doi:10.3969/j.issn.1006-7795.2021.03.004

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (3): 360-366.doi: 10.3969/j.issn.1006-7795.2021.03.004

• Basic and Clinical Research in Neurology Field • Previous Articles Next Articles

Clinical features and difficulties in diagnosis of multiple sclerosis in China

Liu Xiran¹, Xu Yan², Wang Weizhi³, Wang Lihua³, Zhang Meini⁴, Li Chunyang⁵, Dong Huiqing⁶, Li Guozhong⁷, Liu Hongbo⁸, Fu Jin³, Jin Tao⁹, Guan Yangtai¹⁰, Tan Guojun¹¹, Guo Li^11*, Zhang Xinghu^1*

1. Department of Neuroimmunology and Neuroinfectious Diseases, Neurology Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;
2. Department of Neurology, Peking Union Medical College Hospital, Beijing 100140, China;
3. Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China;
4. Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan 030001, China;
5. Department of Neurology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China;
6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
7. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150007, China;
8. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 150007, China;
9. Department of Neurology, The First Affiliated Hospital of Jilin University, Changchun 130031, China;
10. Department of Neurology, Renji Hospital, Medical School, Shanghai Jiaotong University, Shanghai 200001, China;
11. Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050061, China

Received:2021-03-01 Online:2021-06-21 Published:2021-06-16
Contact: *E-mail:guoli6@163.com;xhzhtiantan@hotmail.com
Supported by:
Natural Science Foundation of Beijing (7212029).

Abstract

Abstract: Objective To summarize the clinical features and diagnostic difficulties of multiple sclerosis(MS) in China. Methods Totally 557 patients with MS were retrospectively studied, and the data including analyzed demographic characteristics, clinical characteristics, Kurtzke Expanded Disability Status Scale (EDSS) score, diagnosis type, diagnosis time were collected and analyzed. Results Among the 557 patients, the ratio of female to male was 2.09∶1. The average age of onset was (34.9±11.2) years. The mean duration of disease was (66.8±61.5) months. Relapsing-remitting multiple sclerosis (RRMS) was the main subtype (69.3%). The most common clinical manifestation was motor symptoms (62.1%). Median EDSS score was 2.5. The recurrence frequency was one episode per year in 23.9% patients and one episode in 2 to 4 years in 21.9% patients. 83.9% patients visited the doctor immediately after the onset of the disease, and the average time (0.28±1.11) years. 55.1% patients were diagnosed at their first visit, and the average time being diagnosed was (0.91±2.36) years. Compared with RRMS, the duration, sensory symptoms, sphincter dysfunction and EDSS of progressive MS were significantly increased. Conclusion The clinical characteristics of MS in Chinese population are partly similar to those of Caucasians, such as the age of onset, gender ratio, the composition and proportion of symptoms. Meanwhile, MS in Chinese population showed its own characteristics, such as a lower RRMS proportion and a milder disease severity. The time to diagnosis is still slightly longer than that in some western countries. It is necessary to reduce the time to diagnosis by raising the awareness of the general population and primary care doctors about MS.

Key words: multiple sclerosis, clinical characteristics, diagnosis

CLC Number:

R741.04

Liu Xiran, Xu Yan, Wang Weizhi, Wang Lihua, Zhang Meini, Li Chunyang, Dong Huiqing, Li Guozhong, Liu Hongbo, Fu Jin, Jin Tao, Guan Yangtai, Tan Guojun, Guo Li, Zhang Xinghu. Clinical features and difficulties in diagnosis of multiple sclerosis in China[J]. Journal of Capital Medical University, 2021, 42(3): 360-366.

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Clinical features and difficulties in diagnosis of multiple sclerosis in China

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