Study on the relationship between oxidative stress and lipid metabolism in obese women with polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2021.04.006

Abstract

Abstract: Objective To explore the degree of oxidative stress in obese patients with polycystic ovary syndrome(PCOS) and its relationship with lipid metabolism. Methods From August 2018 to November 2018, 130 cases of PCOS patients in the Gynecological Endocrinology Department of Beijing Gynecology Hospital, Capital Medical University were selected as study group and 40 healthy women with normal weight who were infertile because of fallopian tube factor or male factor or normal physical examination were selected as control group at the same time. According to the body mass index (BMI), PCOS was divided into three groups, with 45 cases in the PCOS group with normal weight, 42 cases in the PCOS group with overweight, and 43 cases in the PCOS group with obesity. The anthropometric indexes, endocrine indexes, metabolic and oxidative stress indexes of all participants were measured. The characteristics of oxidative stress indicators were compared between the PCOS patients and the control group. Results The malondialdehyde (MDA) of the PCOS group with obesity was significantly higher than the other three groups (P<0.05). The superoxide dismutase (SOD) and retinol (RET) of the PCOS group with obesity and the PCOS group with overweight were significantly lower than those of the PCOS group with normal weight. The total antioxidant activity (TAA) and vitamin E (VE) of the PCOS group with obesity and the PCOS group with overweight were significantly lower than those of the control group with normal weight (P<0.05). The oxidation index MDA was positively correlated with BMI, total cholesterol (TC), and triglyceride (TG) (P<0.05), while the antioxidant index SOD and RET were negatively correlated with BMI, waist circumference (WC), TC, and TG (P<0.05). Linear regression analysis indicated that MDA, RET and VE were all affected by group variable. The MDA increased with the increase of the groups according to BMI, with a regression coefficient of 0.214 (P=0.005), The RET and VE decreased with the increase of the groups according to BMI, with a regression coefficient of -0.243 (P=0.001) and -0.174 (P=0.023). The SOD and TAA decreased with the increase of TG, and the regression coefficients were -0.411 (P＜0.001) and -0.269 (P＜0.001), respectively. Conclusion The oxidative stress was an obvious factor in the pathogenesis of PCOS patients with obesity. The decrease of the antioxidant capacity in PCOS patients with obesity was related to the increase of TG, suggesting that obesity may aggravate the oxidative stress process of PCOS patients through lipid metabolism disorders.

Key words: polycystic ovary syndrome, oxidative stress, obesity, pathogenesis

CLC Number:

R711.75

Wang Husheng, Ruan Xiangyan, Cheng Jiaojiao, Alfred O. Mueck. Study on the relationship between oxidative stress and lipid metabolism in obese women with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2021, 42(4): 540-546.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.04.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I4/540

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