Effects of unilateral and bilateral ovariectomy on adipose tissue and uterine weight in rats

doi:10.3969/j.issn.1006-7795.2023.04.003

Abstract

Abstract: Objective To explore the effects of unilateral and bilateral ovariectomy on the weight of adipose tissue and uterus in rats. Methods SD rats aged 10-11 weeks were divided into three groups: sham operation (Sham, n=5), unilateral ovariectomy (U-OVX, n =5) and bilateral ovariectomy (B-OVX, n=6). The weight of interscapular brown adipose tissue (BAT), inguinal subcutaneous adipose tissue (SAT), intra-abdominal visceral adipose tissue (IAAT), and uterus were compared one year after operation. Results Compared with the Sham group, the weight of SAT and IAAT increased in B-OVX group. There was no difference between the Sham group and U-OVX group in SAT and IAAT weight. There was no difference in BAT weight among the three groups. The weight of uterus in B-OVX group was lower than that in the Sham group and U-OVX group, there was no difference between U-OVX group and Sham group. Conclusions Bilateral ovariectomy increased the weight of subcutaneous and intra-abdominal visceral adipose tissue, but unilateral ovariectomy did not affect the weight of subcutaneous and intra-abdominal visceral adipose tissue. Bilateral ovariectomy and unilateral ovariectomy didn't affect the weight of brown adipose. Unilateral ovariectomy did not cause uterine atrophy.

Key words: ovariectomy, brown adipose tissue, subcutaneous adipose tissue, visceral adipose tissue, menopause

CLC Number:

R711

Yang Yu, Ruan Xiangyan, Cheng Jiaojiao, Xu Xin, Alfred O.Mueck. Effects of unilateral and bilateral ovariectomy on adipose tissue and uterine weight in rats[J]. Journal of Capital Medical University, 2023, 44(4): 524-529.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.04.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I4/524

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