Observation of clinical effect of remote ischemic conditioning in patients with spontaneous intracerebral hemorrhage

doi:10.3969/j.issn.1006-7795.2025.02.023

Abstract

Abstract: Objective To evaluate clinical effect of remote ischemic conditioning (RIC) in patients with spontaneous intracerebral hemorrhage (sICH). Methods Sixty-four patients with sICH who were diagnosed and admitted to the Department of Neurosurgery, the Sixth Medical Center of PLA General Hospital from January 2023 to May 2024 were selected as research subjects. Following the principle of matching baseline characteristics between groups, a computerized random grouping program was used to divide them into an observation group of 32 cases and a control group of 32 cases. Patients in the control group received standard basic medication according to the ‘Chinese Clinical Management Guidelines for Cerebrovascular Diseases’，while the observation group received RIC treatment in addition to the control group's treatment, with a course of 14 d. The changes in National Institutes of Health Stroke Scale (NIHSS) scores and Barthel index (BI, daily living ability score table) on the day of admission and after 14 d of treatment, the changes in hematoma volume on computed tomography (CT) imaging, and the incidence of adverse events were compared between the two groups. Results At admission, the difference is not statistically significant in NIHSS scores, BI, and CT imaging hematoma volume between the two groups (P>0.05). After 14 d of treatment, the NIHSS scores of both groups were reduced compared to before treatment, and the scores of the observation group were lower than those of the control group (P<0.05); the BI of both groups was increased compared to before, and the scores of the observation group were higher than those of the control group (P<0.05); there were no significant differences in CT imaging hematoma volume and the incidence of adverse events between the two groups (P>0.05). Conclusion Continuous RIC treatment for 14 d is safe and well-tolerated in patients with spontaneous intracerebral hemorrhage and can effectively improve the neurological function of patients.

Key words: remote ischemic conditioning, intracerebral hemorrhage, neurological function, hematoma volume, spontaneous intracerebral hemorrhage

CLC Number:

R743

Wu Lin, Sun Junzhao, Han Chengchen, Nie Xingxing, Tian Yuhong, Pi Hongying. Observation of clinical effect of remote ischemic conditioning in patients with spontaneous intracerebral hemorrhage[J]. Journal of Capital Medical University, 2025, 46(2): 356-362.

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