Research progress of Piezo mechanosensitive ion channel in overactive bladder

doi:10.3969/j.issn.1006-7795.2025.04.025

Abstract

Abstract: In order to explore the role of Piezo mechanosensitive ion channel in overactive bladder (OAB), it provides a new idea for the clinical treatment of bladder dysfunction. This paper systematically reviews the importance and characteristics of Piezo1 and Piezo2 in the bladder, including their biophysical properties, localization, and function, with a particular focus on their connection to the pathophysiology of OAB. Although it is still too early to fully uncover the exact mechanism by which the Piezo channel regulates bladder function, altering urination function by inhibiting the Piezo1/2 channel as a new therapeutic strategy for OAB, based on existing research. With the further study of Piezo channel, it will undoubtedly become a potential target and therapeutic strategy for the treatment of OAB.

Key words: mechanosensitive cation channels, Piezo1, Piezo2, overactive bladder, urothelium, urinary incontinence

CLC Number:

Shi Jiahui. Research progress of Piezo mechanosensitive ion channel in overactive bladder[J]. Journal of Capital Medical University, 2025, 46(4): 749-753.

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