Correlation between hemoglobin and gestational diabetes mellitus in early pregnancy

doi:10.3969/j.issn.1006-7795.2026.01.010

Abstract

Abstract: Objective To investigate the relationship between the hemoglobin levels in early pregnancy and risk of gestational diabetes mellitus (GDM). Methods Clinical data of 1 044 pregnant women without preconception diabetes who gave birth in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 1, 2024 to June 30, 2024 were selected, and their age, preconception body mass index (BMI) and the results of the first hemoglobin laboratory test in early pregnancy(at 6－10 weeks of gestations) were collected. According to the results of oral glucose tolerance test (OGTT) in the second trimester, the patients were divided into GDM group(173 cases) and non-GDM group(871 cases). Logistic regression was used to analyze the relationship between hemoglobin (HGB) and GDM in the first trimester. Results In this study, the incidence of GDM was 16.57%, The Age, BMI and HGB in the early pregnancy of the GDM group were all higher than those of the non-GDM group, and the differences were statistically significant (P < 0.05). The HGB in the early pregnancy was significantly positively correlated with the blood glucose at 0 h (r= 0.069, P=0.025), 1h (r=0.15, P < 0.001) and 2 h (r=0.124, P<0.001) of OGTT in the mid-pregnancy. HGB concentration in the first trimester was an independent risk factor affecting the occurrence of GDM (OR=1.02,95%CI:1.004－1.046, P=0.021)，and after stratification by age and BMI,HGB levels in the early pregnancy stage remained an independent risk factor for the occurrence of GDM (all P<0.05), and the results were reliable.As the HGB level rises during the early stage of pregnancy, the risk of developing GDM increases. Conclusion The increase of HGB level in early pregnancy is significantly correlated with the occurrence of GDM, which has predictive value for the occurrence of GDM.

Key words: early pregnancy, gestational diabetes mellitus, hemoglobin, risk factors, blood glucose, predictive value

CLC Number:

R714.2

Han Wenli, Zou Liying, Zheng Wei, Zhao Yue. Correlation between hemoglobin and gestational diabetes mellitus in early pregnancy[J]. Journal of Capital Medical University, 2026, 47(1): 82-86.

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