Abstract: Caloric restriction(CR) is a kind of dietary mode that decreases calories intake by 30%~50% under the premise of nutritional adequacy. It has aroused increasing attention that CR can extend lifespan of organism, delay or prevent the occurrence and development of several ageing-related diseases. There are several mechanisms proposed to explain the neuroprotective effects of caloric restriction: antioxidant effects, increased metabolic efficiency, increased sirtuin and neurotrophic factor activity, and anti-inflammatory effects.

Key words: caloric restriction, neuroprotection, sirtuin