Effect of Autologous Mononuclear Bone Marrow Cell Implantation on the Plasm Level of Urotensin-Ⅱ and Endothelin-1 in Patients with Acute Myocardial Infarction

doi:10.3969/j.issn.1006-7795.2010.01.022

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (1): 99-102.doi: 10.3969/j.issn.1006-7795.2010.01.022

Effect of Autologous Mononuclear Bone Marrow Cell Implantation on the Plasm Level of Urotensin-Ⅱ and Endothelin-1 in Patients with Acute Myocardial Infarction

XU Hong-tao^1,2, GAO Lian-ru², ZHANG Ning-kun², ZHU Zhi-ming², FEI Yu-xing², YANG Ye², WANG Zhao-jun², LIU Ying-ming², CAO Yi², CHEN Yu², LI Xian-feng²

1. Department of Gerontology, Navy General Hospital; 2. Department of Cardiology, Navy General Hospital

Received:1900-01-01 Revised:1900-01-01 Online:2010-02-21 Published:2010-02-21
Contact: XU Hong-tao

Abstract

Abstract:

Objective To study the effect of intracoronary implantation of autologous mononuclear bone marrow cell(MBMC) on the plasma level of urotensin-Ⅱ(U-Ⅱ) and endothelin-1(ET-1) in patient with acute myocardial infarction(AMI). Methods Twenty-three patients with AMI who underwent intracoronary implantation of autologous MBMC were enrolled in this study. UⅡ and ET-1 levels were measured by radioimmunoassay. Results The U-Ⅱ level in AMI patients was lower than that of control group〔(0.223±0.043)mg/L, vs (0.462±0.115)mg/L, P<0.05〕. After MBMC implantation, U-Ⅱ levels increased to 129% on day one compared to pre-transplantation. Whereas ET-1 levels decreased to 61%(compared with pre-transplantation) one day after cell infusion. And both U-Ⅱ and ET-1 slightly increased again 7 days after transplantation compared with 1 day after transplantation. Conclusion The therapeutic effect of MBMC transplantation may be related to the changes of ET-1 and UⅡ plasma level.

Key words: acute myocardial infarction, intracoronary implantation of autologous mononuclear bone marrow cell, human urotensin-Ⅱ, endothelin-1

CLC Number:

R 541.4

XU Hong-tao, GAO Lian-ru, ZHANG Ning-kun, ZHU Zhi-ming, FEI Yu-xing, YANG Ye, WANG Zhao-jun, LIU Ying-ming, CAO Yi, CHEN Yu, LI Xian-feng. Effect of Autologous Mononuclear Bone Marrow Cell Implantation on the Plasm Level of Urotensin-Ⅱ and Endothelin-1 in Patients with Acute Myocardial Infarction[J]. Journal of Capital Medical University, 2010, 31(1): 99-102.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2010.01.022

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2010/V31/I1/99

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Effect of Autologous Mononuclear Bone Marrow Cell Implantation on the Plasm Level of Urotensin-Ⅱ and Endothelin-1 in Patients with Acute Myocardial Infarction

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