Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (1): 99-102.

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Effect of Autologous Mononuclear Bone Marrow Cell Implantation on the Plasm Level of Urotensin-Ⅱ and Endothelin-1 in Patients with Acute Myocardial Infarction

XU Hong-tao1,2, GAO Lian-ru2, ZHANG Ning-kun2, ZHU Zhi-ming2, FEI Yu-xing2, YANG Ye2, WANG Zhao-jun2, LIU Ying-ming2, CAO Yi2, CHEN Yu2, LI Xian-feng2   

  1. 1. Department of Gerontology, Navy General Hospital; 2. Department of Cardiology, Navy General Hospital
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-21 Published:2010-02-21
  • Contact: XU Hong-tao

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Abstract:

Objective To study the effect of intracoronary implantation of autologous mononuclear bone marrow cell(MBMC) on the plasma level of urotensin-Ⅱ(U-Ⅱ) and endothelin-1(ET-1) in patient with acute myocardial infarction(AMI). Methods Twenty-three patients with AMI who underwent intracoronary implantation of autologous MBMC were enrolled in this study. UⅡ and ET-1 levels were measured by radioimmunoassay. Results The U-Ⅱ level in AMI patients was lower than that of control group〔(0.223±0.043)mg/L, vs (0.462±0.115)mg/L, P<0.05〕. After MBMC implantation, U-Ⅱ levels increased to 129% on day one compared to pre-transplantation. Whereas ET-1 levels decreased to 61%(compared with pre-transplantation) one day after cell infusion. And both U-Ⅱ and ET-1 slightly increased again 7 days after transplantation compared with 1 day after transplantation. Conclusion The therapeutic effect of MBMC transplantation may be related to the changes of ET-1 and UⅡ plasma level.

Key words: acute myocardial infarction, intracoronary implantation of autologous mononuclear bone marrow cell, human urotensin-Ⅱ, endothelin-1

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