Abstract: Objective To observe the serum levels of vascular endothelial growth factor(VEGF) and endostatin in patients with non-small cell lung cancer(NSCLC); offer the Objective basis for estimating the patient's condition and prognosis. Methods Eighty-two patients with stage ⅡB-Ⅲ non-small cell lung cancer were randomly selected and invided into two groups according to the diagnostic criteria of syndrome of qi-deficiency and blood stasis(SQDBS). The serum level of VEGF and endostatin was detected by enzyme linked immunosorbent assay. Results Serum level of VEGF and endostatin was significantly higher in patient with the syndrome of SQDBS than in patient without the SQDBS; SQDBS was the key factor which had an effect upon these indexes. Conclusion Objective inner links are found between the SQDBS of NSCLC and VEGF, endostatin; the serum level of VEGF and endostatin can be served as the pathological basis of SQDBS in microcosmic; non-small cell lung cancer patients with SQDBS may be at a greater risk of diversion than patients without SQDBS.

Key words: syndrome of qi-deficiency and blood stasis, non-small cell lung cancer, vascular endothelial growth factor, endostatin