Journal of Capital Medical University ›› 2001, Vol. 22 ›› Issue (2): 135-137.

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Study on Plasma Levels of Endothelin-1 and Urinary Excretion Rate of Endethlin in Chronic Glomerulonephritis Patients with Renal Hypertension

Shi Lei1, Zhao Yiwen1, Zhang Xiaoping Shan Ruoming1   

  1. 1. Department of Nephrology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences;2. Clinic Analysis Laboratory, Capital University of Medical Sciences
  • Received:2000-11-20 Revised:1900-01-01 Online:2001-04-15 Published:2001-04-15

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Abstract:

To elucidate the effects on renal hypertension and progressive renal disease of endothelin 1 in patients of chronic glomerulonephritis, plasma endothelin 1(PET-1), urinary excretion rate of endothelin 1(UET-1), creatinine clearance(Ccr)and urinary excretion rate of β2- microglobulin(β-m)in 54 patients with chronic glomerulonphritis and those in 20 normal control were measured. The Results indicated the level of PET-1 and UET-1 in all patients was markedly elevated. There was a positive correlation between PET-1 or UET-1 and mean ertery pressure(MAP)and a negative relation between the former and β-m. Correlation between PET-1 or UET-1 and Ccr were found. Endothelin plays an important role in developing renal hypertension and in porgressive renal disease and also UET-1 is a sensitive marker of renal tubular damage.

Key words: renal hypertension, endothelin, creatinine clearance, &beta, 2-microglobulin

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