Abstract:

Objective To evaluate whether the nonhypertension lowing dosage of spironolactone, was able to prevent the renal arterioles remoderlling in Nω-nitro-L-arginine-methyl ester(L-NAME) and salt induced hypertensive rat. Methods Twenty-two male SDrats were divided into 3 groups randomly: group received tap water (C) as control, group 2 received L-NAME (L), group 3 received L-NAME plus spironolactone by gastric gavage (S). All the rats were fed with 1% salt water except the rats in group C. Eight weeks later biochemical assessment of serum were evaluated. The vessel chamber diameter (CD)and area(CA), the vessel middle layer thickness(MT) and area(MA) and the ratio of middle layer thickness to chamber diameter(M/C) were calculated by microscopy observation, the ratio of middle layer fiber area to middle layer area was determined. Results The blood pressure in group Land Sshowed an expected hypertension compared with those in group C(P<0.01), and there is no significant different between group Land S(P>0.05). Significant differences were found in the CD, MT, CA, M/Cand the fibrosis in the middle layer of renal arterioles between Land C, S. Conclusion The nonhypertension lowing dosage of spironolactone can prevent the renal arterioles remoldelling effectively.

Key words: hypertension, vascular remodeling, aldosterone