Abstract: Observations of pathologic morphology were made at the early phase of acute hemorrhagic and necrotic pancreatitis(AHNP), to investigate pathogenesis of acute pancreatitis.AHNP was induced in rats(30, weight 300～350 g) by intraductal administration of 5% sodium taurocholate.The pathologic morphologic changes of pancreatic tissue were examined by light microscope by HE and PTH and electron microscope after induced 5 min to 6 h.Main pathological changes: hemorrhage and necrosis appear in pancreas, fibrin thrombus, white thrombus and mixed thrombus in small vessels.With the development of the disease pathological changes were aggravated.The result suggests: AHNP is associated with self-digestion and microcirculation disturbance.

Key words: acute hemorrhagic and necrotic pancreatitis (AHNP), pathologic change, self-digestion, microcirculation disturbance