Progress in studies on the role of cytokine in pathogenesis and treatment of HIV infection

doi:10.3969/j.issn.1006-7795.2012.05.014

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (5): 625-628.doi: 10.3969/j.issn.1006-7795.2012.05.014

• 艾滋病神经认知损害及疫苗学研究 • Previous Articles Next Articles

Progress in studies on the role of cytokine in pathogenesis and treatment of HIV infection

ZHANG Mei, WU Hao, ZHANG Hong-wei

Department of Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069, China

Received:2012-07-19 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

Abstract

Abstract: Immune activation is an important feature of HIV infection. CD₄ T-cell immune activation is driven by homeostatic response and inflammation, while CD₈ T cell immune activation is driven by HIV replication and inflammation. Interleukin-7(IL-7), type I interferon and inflammatory cytokines play an important role in the pathogenesis of HIV infection. The role of γc cytokines and interferon alpha in the treatment of HIV infection is still in clinical research stage, which will be helpful for the recovery of immune cells.

Key words: HIV infection, immune activation, cytokines

CLC Number:

R 512.91

ZHANG Mei;WU Hao;ZHANG Hong-wei. Progress in studies on the role of cytokine in pathogenesis and treatment of HIV infection[J]. Journal of Capital Medical University, 2012, 33(5): 625-628.

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Progress in studies on the role of cytokine in pathogenesis and treatment of HIV infection

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