Abstract: Objective To study the role of angiotensin 1-7 inhibitor A779 on glycometabolism and other metabolic indexes to explore a new way in curing diabetes and its complications. Methods Received a A779 was continuously infused to c57bl/s mice by subcutaneous implantation of an osmotic minipump. Glucose-tolerance tests, insulin-tolerance tests and determination of fasting plasma insulin were performed to evaluate glycometablism. Level of blood triglyceride, cholesterol and angiotensin Ⅱ were assayed. Results Compared with the control group, A779 group mice displayed an impairment of glucose tolerance and an increase of fast insulin secretion. HOMA index of A779 group was increased. Conclusion A779 can affect glucose tolerance and insulin secrection, which suggest that angiotensin 1-7 may have a protective effect on the islet function.

Key words: angiotensin-converting enzyme 2, angiotensin(1-7), A779, islet function