Recent progress in studies on the role of Zn2+ in cerebral ischemia

doi:10.3969/j.issn.1006-7795.2013.01.014

Abstract

Abstract:

Recent reports have indicated that zinc ion (Zn²⁺) plays an important role in the mechanism of brain injury following cerebral ischemia. Large amount of Zn²⁺ is released from synaptic vesicles and accumulates in postsynaptic neurons following cerebral ischemia. In addition, oxidative stress and acidosis, both of which occur prominently in ischemia, can induce Zn²⁺ release from zinc-ligands such as metallothionein proteins. Intense cytosolic Zn²⁺ overloads can promote pronounced mitochondrial dysfunction and reactive oxygen species generation to trigger necrosis, whereas milder cytosolic Zn²⁺ loads may augment apoptotic pathways. Further investigation of the contribution of Zn²⁺ to the mechanism of brain injury following cerebral ischemia will likely provide new preventive and therapeutic strategies for ischemic stroke.

Key words: Zn²⁺, cerebral ischemia, brain injury

CLC Number:

R743.31

LI Sen, LIU Kejian, ZHAO Yongmei. Recent progress in studies on the role of Zn²⁺ in cerebral ischemia[J]. Journal of Capital Medical University, 2013, 34(1): 75-79.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.01.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I1/75

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Recent progress in studies on the role of Zn²⁺ in cerebral ischemia

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