Progress in studies of MicroRNA-144-associated diseases and related mechanism

doi:10.3969/j.issn.1006-7795.2013.01.015

Abstract

Abstract:

MicroRNAs (miRs) play a prominent role in a variety of physiological, pathological and biological processes, including the individual development, cell proliferation, differentiation, apoptosis, and oncogenesis by binding to target transcripts for cleavage or translational repression. Recently, a new class of miRs called ‘circulating miRs’ was found in cell-free body fluids such as plasma and urine. Circulating miRs have been shown to be very stable, specific, and sensitive biomarkers. Among the identified miRs thus far, ~50% of mammalian miRs are clustered in the genome and transcribed as polycistronic primary transcripts. Recent studies have demonstrated that miR-144 is the important regulator of erythroid differentiation, and is involved in the tumor development and cardio-cerebrovascular disease. The pre-miR-144 exists as bicistronic locus miR-144/451, and this article reviews the effect and possible regulating mechanisms of miR-144 in the blood disease, disorder of the nervous system, cancer, heart disease based on recently published literature.

Key words: microRNA-144, erythropoiesis, leukemia, cancer, myocardial ischemia

CLC Number:

R743

ZHAO Haiping, LUO Yumin. Progress in studies of MicroRNA-144-associated diseases and related mechanism[J]. Journal of Capital Medical University, 2013, 34(1): 80-85.

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