Clinical applications of urapidil in cardiovascular disease

doi:10.3969/j.issn.1006-7795.2013.01.019

Abstract

Abstract:

Urapidil, which is a phenyl piperazine substituted uracil derivatives, is a peripheral postsynaptic alpha 1-adrenoceptor antagonist with central agonistic action at serotonin (5-HT)-1, It was widely used in lowering blood pressure and with a wide range of indications (such as: critical hypertension, prophylaxis of hypertensive peaks and treatment of hypertension during surgery) through decreasing peripheral vascular resistance. It is also a moderate pre-synaptic alpha 2-adrenoceptor agonist with a weak beta 1-blocking effect. It can reduce the pre- and after-load of the heart by reducing the venous blood return and blocking the release of catecholamine with potential clinical applications in congestive heart failure and ischemic heart disease with few side effects. This review was written to summarize and evaluate the clinical application of urapidil in cardiovascular disease.

Key words: urapidil, cardiovascular disease, clinical application

CLC Number:

R543.3

HE Jingyu, HUA Qi. Clinical applications of urapidil in cardiovascular disease[J]. Journal of Capital Medical University, 2013, 34(1): 100-104.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.01.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I1/100

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