Abstract: Objective To evaluate the effect of replenishing Qi and nourishing Yin to promote the blood circulation on 103 patients with acute myocardial infarction(AMI) after reperfusion and observe the change of myocardial microcirculation. Methods A total of 103 patients with AMI who underwent successful immediate percutaneous coronary intervention(PCI) were randomized into two groups. Patients were treated with either Salvia and Ginseng of traditional Chinese medicine(TCM) group or fecula of corn in placebo group for three months. All patients were examined with myocardial contrast echocardiography(MCE) before and after 3-month treatment. Three indexes of myocardial microcirculation, i.e., left ventricular ejection fraction(LVEF), normal cardiac muscle percentage(NCMP), and the number of the segments where value A(contrast agent intensity) was improved significantly(NA) were assessed. Results Compared with the three indexes of the two groups at the 3rd month in the state of dobutamine stress(DS), all indexes were increased. After 3 months of treatment, LVEF, NCMP and NA of TCM group were higher than those of the placebo group(P<0.05 for all). LVEF of TCM group after 3-months treatment was higher than that of pre-treatment level(P<0.05). Compared with the three indexes between the two groups before and after treatment, LVEF and NA of TCM group increased significantly(P<0.05). Conclusion TCM with the effect of replenishing Qi and nourishing Yin to promote the blood circulation could be beneficial to myocardium microcirculation perfusion and improve the quality of life of the AMI patients who had successful reperfusion.

Key words: replenishing Qi and nourishing Yin to Promote the blood circulation, acute myocardial infarction, reperfusion, myocardial contrast echocardiography