Abstract:

Objective To provide clinical evidence for standardized strategy through the comprehensive treatment for polycystic ovary syndrome(PCOS) patients. Methods A total of 30 participants were recruited from PCOS patients who came to Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University for irregular menstruation and/or infertility between August 2012 and May 2013. The comprehensive treatment included individualized nutrition, exercise, and drug therapy. The individualized nutrition and exercise guidance were based on static metabolic rate and motor function of body composition measured. Drug therapy included ethinylestradiol and cyproterone acetate tablets(Diane-35) for three cycles;metformin for 3 months continuously for patients whose fasting plasma glucose and/or insulin was high, combined with diet, exercise and modifications in lifestyle. Their clinical and biochemical parameters were measured, including height, weight, waist circumference(WC), hip circumference(HC), sagittal abdominal diameter(SAD), body fat(BF), follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T), fasting plasma glucose(GLU), fasting insulin[INS(OH)], total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C), apolipoprotein A-Ⅰ(Apo A-Ⅰ), apolipoprotein B(Apo B) and C reactive protein(CRP). Results Comprehensive treatment for 3 months, BMI, BF, LH/FSH, T, GLU and HOMA-IR were lower, P<0.05; WHR, SAD, ISI and blood lipid level had no significant difference, P>0.05. Conclusion Comprehensive treatment has an important role in efficacy and prognosis for PCOS and provide preliminary clinical evidences for standardized treatment of PCOS.

Key words: polycystic ovary syndrome, comprehensive treatment, nutrition, exercise, drug