Analysis on risk factors of colorectal polyps

doi:10.3969/j.issn.1006-7795.2013.05.010

Abstract

Abstract:

Objective To investigate the risk factors that may be associated with colorectal polyps. Methods Patients who underwent complete colonoscopy at Peking Union Medical College Hospital endoscopy center between June 1, 2012 and May 31, 2013 were enrolled into this study. These patients were divided into polyps group and normal control group. Each case undertook the same questionnaire about their general situation and endoscopic polyps performance. The data were statistically analyzed by using SAS 9.2. Results Totally 106 colorectal polyps patients were enrolled into the polyps group and 383 normal persons were enrolled into control group. Multivariate logistic regression analyses were performed. Age (OR=1.343, 95%CI:1.063-1.697), family history of cancer (OR=3.013,95%CI:1.675-5.419) and high proportion of red meat intake (OR=1.650, 95%CI: 1.085-2.509) were independent risk factors for colorectal polyps. Adenomatous polyps was easier to be detected in male than in female (P<0.05) and the proportion of patients with adenomatous polyps increased with age (P<0.05). Conclusion Age, family history of cancer and high proportion of red meat intake are independent risk factors for colorectal polyps, while high proportion of fresh fruits and vegetables intake are protective factors. Elderly male patients may have increase risk to occur adenomatous polyps. Risk factors questionnaire is useful in screening for colorectal tumors.

Key words: colorectal polyps, colorectal cancer, risk factors, screening

CLC Number:

R574.6

LI Yanping, LI Ji, GAI Xiaorong, WU Jun, LI Wenbin, WU Dong, YAO Fang, LI Jingnan. Analysis on risk factors of colorectal polyps[J]. Journal of Capital Medical University, 2013, 34(5): 684-688.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.05.010

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I5/684

References

[1] Jemal A, Bray F, Center M M, et al. Global cancer statistics[J]. CACancer J Clin, 2011,61(2): 69-90.
[2] 万德森.结直肠癌流行趋势及其对策[J]. 癌症, 2009,28(9):897-902.
[3] Ries L A G, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975－2005[R]. Bethesda, MD: National Cancer Institute, 2008.
[4] Allen J I. Molecular biology of colon polyps and colon cancer[J]. Semin Surg Oncol, 1995,11(6):399-405.
[5] U.S. Preventive Services Tast Force. Screening for colorectal cancer: U.S. preventive services task force recommendation statement[J]. Ann Intern Med, 2008,149(9):627-637.
[6] Bretthauer M, Kalager M. Colonoscopy as a triage screening test[J]. N Engl J Med, 2012,366(8):759-760.
[7] 吴军,钱家鸣,盖小荣,等.529例健康体检者结肠镜检查结果分析[J].中华消化内镜杂志,2012,5(29):272-275.
[8] 黄彦钦,蔡善荣,张苏展,等.中国结直肠癌人群筛查方案的应用价值初探[J].中华预防医学杂志, 2011,45(7):601-604.
[9] Chiu H M, Wang H P, Lee Y C, et al. A prospective study of the frequency and the topographical distribution of colon neoplasia in asymptomatic average-risk Chinese adults as determined by colonoscopic screening[J]. Gastrointest Endosc, 2005,61(4):547-553.
[10] Parkin D M. Global cancer statistics in the year 2000[J]. Lancet Oncol, 2001,2(9):533-543.
[11] Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths[J]. CA Cancer J Clin, 2011, 61(4): 212-236.
[12] Ferlay J, Parkin D M, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008[J]. Eur J Cancer, 2010, 46(4): 765-781.
[13] Jemal A, Center M M, Desantis C, et al. Global patterns of cancer incidence and mortality rates and trends[J]. Cancer Epidemiol Biomarkers Prev, 2010,19(8):1893-1907.
[14] 魏晓为, 陈锦飞.结肠炎相关结直肠癌认识的进展[J].中华肿瘤防治杂志,2010,17(21)1795-1798.
[15] Zauber A G, Winawer S J, O'Brien M J, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths[J]. N Engl J Med, 2012,366(8):687-696.
[16] Winawer S, Fletcher R, Rex D, et al. Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence[J]. Gastroenterology, 2003,124(2):544-560.
[17] Grahn S W,Varma M G. Factors that increase risk of colon polyps[J]. Clin Colon Rectal Surg, 2008,21(4): 247-255.
[18] Michels K B,Giovannucci E,Chan A T, et al. Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health Study[J]. Cancer Res, 2006,66(7):3942-3953.
[19] Pox C P, Altenhofen L, Brenner H, et al. Efficacy of a nationwide screening colonoscopy program for colorectal cancer[J]. Gastroenterology, 2012,142(7):1460-1467.
[20] 谭振刚, 许海楠,孙旭.CT结肠镜诊断结直肠肿瘤和息肉准确性的系统评价[J].中华肿瘤防治杂志,2011,18(5):361-366.