Clinical value of fluorescence in situ hybridization in early detection of postoperative recurrence of bladder urothelial cancer

doi:10.3969/j.issn.1006-7795.2014.03.007

Abstract

Abstract:

Objective To early diagnose postoperative recurrence of bladder urothelial cancer with fluorescence in situ hybridization(FISH).Methods Forty patients with bladder urothelial cancer were chosen between January, 2009 and November, 2011. Urine cytologic examination, cystoscopy, and FISH were performed in these patients at 3, 6, 9, 12, and 18 months post-operation, and tumor recurrence was recorded. Results Among the 40 patients tested, 12 of 20 FISH-positive patients developed tumor recurrence within the follow-up period, while none of the FISH-negative patients developed recurrence during the same period. The recurrence rate in FISH-positive patients(60%) was significantly higher than that of FISH-negative patients(P<0.05). The sensitivity to detect tumor recurrence by FISH analysis was higher than that by cystoscopy and urine cytologic examination. Conclusion FISH analysis is effective in early detection of postoperative recurrence of bladder urothelial cancer.

Key words: bladder cancer, fluorescence in situ hybridization, recurrence, prediction

CLC Number:

Yan Wei, Kang Wenting, Chen Shan, Liu Yuexin. Clinical value of fluorescence in situ hybridization in early detection of postoperative recurrence of bladder urothelial cancer[J]. Journal of Capital Medical University, 2014, 35(3): 298-301.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.03.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I3/298

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