Changes of anti-Mullerian hormone（AMH） and inhibin B（INHB） during controlled ovarian hyperstimulation in polycystic ovarian syndrome

doi:10.3969/j.issn.1006-7795.2014.04.004

Journal of Capital Medical University ›› 2014, Vol. 35 ›› Issue (4): 402-406.doi: 10.3969/j.issn.1006-7795.2014.04.004

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Changes of anti-Mullerian hormone（AMH） and inhibin B（INHB） during controlled ovarian hyperstimulation in polycystic ovarian syndrome

Li Ying, Nie Mingyue, Fang Ying, Yang Xiaokui

Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026

Received:2014-06-10 Online:2014-08-21 Published:2014-07-22
Supported by:
This study was supported by Natural Science Foundation of China(81170542); Beijing Municipality Health Technology High-level Taltent(2011-3-071); Project of Discipline Leader, Beijing Obstetrics and Gynecology Hospital, Capital Medical University(2013-2).

Abstract

Abstract:

Objective To explore dynamics of anti-Müllerian hormone(AMH) and inhibin B(INHB) during controlled ovarian hyperstimulation(COH) in polycystic ovarian syndrome(PCOS), and assess the value of these dynamic changes on the prediction of outcome in PCOS patients undergoing in vitro fertilization(IVF). Methods Thirty-seven women with PCOS and 41 women with normal ovarian reserve as the control were recruited in the study. AMH and INHB levels were measured in serum on menstrual cycle day 2 or 3(D2/3), day 5 of gonadotropin stimulation(D5), human chorionic gonadotropin(hCG) day (D-hCG) and follicular fluid(FF) on oocyte retrieval day during IVF treatment, and the relationship of AMH and INHB levels with COH outcomes was analyzed. Results (1) AMH levels gradually decreased while INHB levels gradually increased from D2/3 to D-hCG during COH procedure. (2) Significant differences were observed in estradiol(E2) levels of hCG day, gonadotrophin(Gn) dosage, retrieved oocytes, fertilization rate and frozen embryos(P<0.05) in PCOS and control groups. (3) There was a negative correlation in serum AMH and INHB levels on D2/3, D5 and D-hCG with Gn dosage, positive correlation with estradiol of hCG day(P<0.05, P<0.001), no correlation with oocytes retrieval and clinical pregnancy rate(P>0.05). Conclusion Serum AMH and INHB levels are demonstrated to have dynamic changes during COH procedure in PCOS patients, and reflect the ovarian response in COH. The predictive value of AMH and INHB on COH outcomes in PCOS remains to be evaluated via further research.

Key words: polycystic ovarian syndrome(PCOS), controlled ovarian hyperstimulation(COH), anti-Mü, llerian hormone(AMH), inhibin B(INHB)

CLC Number:

R711.75

Li Ying, Nie Mingyue, Fang Ying, Yang Xiaokui. Changes of anti-Mullerian hormone（AMH） and inhibin B（INHB） during controlled ovarian hyperstimulation in polycystic ovarian syndrome[J]. Journal of Capital Medical University, 2014, 35(4): 402-406.

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Changes of anti-Mullerian hormone（AMH） and inhibin B（INHB） during controlled ovarian hyperstimulation in polycystic ovarian syndrome

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