Distribution of dopamine receptors in gastric mucosal somatostatin-secreting cell of human and mice

doi:10.3969/j.issn.1006-7795.2015.03.018

Abstract

Abstract:

Objective To investigate the distribution of dopamine D₁, D₂ receptors in somatostatin-secreting D cells in gastric corpus mucosa in human and mice. Methods Immunofluorescence was used to detect the expression of dopamine receptors on the somatostatin-secreting D cells in human or mice gastric corpus. Results Abundant immunofluorescence reactivities (IR) of dopamine D₁ and D₂ receptors, and somatostatin-IR cells were distributed in the gastric corpus mucosa. Furthermore, D₂ receptors-IR, not D₁ receptors-IR, was observed in the somatostatin-IR cells of mice and human gastric corpus mucosa. Conclusion Dopamine D₂ receptors, not D₁ receptors were distributed in the gastric somatostatin-secreting D cells of both human and mice, which might mediate the regulation of dopamine on the somatostatin secretion, gastric secretion and motility.

Key words: somatostatin, dopamine receptors, gastric D cell

CLC Number:

R333

Sun Lu, Feng Xiaoyan, Zheng Lifei, Zhang Xiaoli, Zhang Yue, Zhu Jinxia. Distribution of dopamine receptors in gastric mucosal somatostatin-secreting cell of human and mice[J]. Journal of Capital Medical University, 2015, 36(3): 432-436.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.03.018

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I3/432

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