Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin

doi:10.3969/j.issn.1006-7795.2015.05.022

Abstract

Abstract: Objective To investigate the relationship between the nonalcoholic fatty liver disease (NAFLD) diagnosed by ultrasonography and serum iron and ferritin. Methods Forty patients with NAFLD (case group) and forty normal persons(control group) were examined by ultrasonic diagnosis, the levels of serum iron and serum ferritin were detected by atomic absorption spectrum method and radioimmunoassay respectively. Results The level of serum iron and serum ferritin in case group were (105.17±24.52)μg/dL,(146.57±68.28)ng/dL, the level of serum iron and serum ferritin in control group were (85.45±26.84)μg/dL,(90.58±49.71)ng/dL, respectively.The difference in serum iron and serum ferritin was significantly different between NFALD patients and normal control (P<0.01). The area under receiver operating characteristic (ROC) curve diagnosing NAFLD by serum iron and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.69(P<0.01),123.5 (μg/dL),82.5%,60%,40 %,17.5% respectively. The area under ROC curve diagnosing NAFLD by serum ferritin and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.73(P<0.01),134.9 (ng/dL),75.0%,72.5%,27.5%,25.0% respectively. Conclusion The levels of serum iron and serum ferritin were higher in NAFLD patients. The rise of serum iron and serum ferritin is coincide with NAFLD diagnosed by ultrasonography.

Key words: non-alcoholic fatty liver disease, serum iron, serum ferritin, ultrasonography

CLC Number:

Q575

Zhang Wenping, Wu Jing, Ren Meijie, Chen Yanxing, Li Kechun, Yang Peiyi, Yang Jiaxnwei, Wang Mengnan, Nie Meiling. Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin[J]. Journal of Capital Medical University, 2015, 36(5): 778-781.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.05.022

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I5/778

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