Relationship between progesterone-regulated microRNAs and breast cancer

doi:10.3969/j.issn.1006-7795.2017.04.007

Abstract

Abstract: microRNAs(miRNAs) are a class of small non-coding RNAs that regulate the expression of multicellular eukaryotic genes at post-transcriptional levels. miRNA mutations or abnormal expressions are associated with various human cancers. miRNAs can function as tumour suppressors and oncogenes. Progesterone receptors (PR) mediate response to progestins in the normal breast and breast cancer. Progesterone exposure is a recognized risk factor for postmenopausal breast cancer, especially synthetic progesterone. Several studies have shown that hormonal regulated miRNAs have an important role in hormone receptor mediated gene regulation. Progesterone regulated miRNAs can affect the expression of progesterone receptors and their activities. Therefore, further studies are needed to dissect the gene regulations and molecular mechanisms related to progestine, PR and miRNAs. The diagnostic, therapeutic and prognostic potential of these miRNAs in breast cancer should be further evaluated.

Key words: breast cancer, progesterone, progeterone receptor, microRNAs, gene regulation, molecular mechanisms

CLC Number:

R737.9

Wang Lijuan, Yang Chun, Gu Muqing, Pierre Hardy, Ruan Xiangyan, Alfred O. Mueck. Relationship between progesterone-regulated microRNAs and breast cancer[J]. Journal of Capital Medical University, 2017, 38(4): 521-525.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.04.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I4/521

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