Endocrine characteristics of diminished ovarian reserve in Chinese women with polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2017.04.006

Abstract

Abstract: Objective To assess the prevalence of diminished ovarian reserve (DOR) in patients with polycystic ovary syndrome (PCOS) in China, and to investigate the endocrine characteristics of these patients.Methods Totally 338 PCOS women and 68 simple DOR women, who came to Department of Gynecological Endocrinology in Beijing Obstetrics and Gynecology Hospital between January 2015 and January 2017 were recruited.Age and menstruation of these patients were recorded. Body height, body weight, waist circumference, hip circumference, basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), testosterone(T),anti-Müllerian hormone (AMH) and baseline antral follicle count (bAFC) of these patients were measured. The differences of indices between PCOS with DOR,simple PCOS and simple DOR were analyzed with analysis of variance. Results (1) The prevalence of DOR in our Chinese PCOS patients was 16.9%.(2)In PCOS with DOR patients, the prevalence of basal FSH value>10IU/L, FSH/LH ratio>3,basal estradiol (E₂)>80 pg/mL and baseline antral follicle count (bAFC) fewer than four were 38.6%,35.1%,35.1% and 36.8%,respectively. The basal FSH and testosterone in PCOS with DOR patients were different from both simple PCOS and simple DOR patients(P<0.05). The basal estradiol, FSH/LH ratio,AMH in PCOS with DOR patients had significant differences from simple PCOS patients(P<0.05),while had no difference from simple DOR patients. (4)In simple PCOS patients,AMH had a positive correlation with testosterone(P<0.01).In PCOS with DOR patients, AMH had a negative correlation with FSH(P<0.01),while had a positive correlation with LH(P<0.01).In simple DOR patients, AMH had a negative correlation with age,FSH,LH and FSH/LH ratio(P<0.01).Conclusion The endocrine characteristics of PCOS with DOR patients are different from simple PCOS patients as well as simple DOR patients.

Key words: polycystic ovary syndrome, diminished ovarian reserve, sex hormones, anti-Müllerian hormone

CLC Number:

R711.75

Jin Jing, Ruan Xiangyan, Hua Lin, Tian Xuanxuan, Li Yanglu, Wang Lijuan, Zhao Yue, Alfred O. Mueck. Endocrine characteristics of diminished ovarian reserve in Chinese women with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2017, 38(4): 515-520.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.04.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I4/515

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