Relationship between RDW, neutrophil/lymphocyte ratio and endothelial function in essential hypertensive patients

doi:10.3969/j.issn.1006-7795.2018.02.025

Abstract

Abstract: Objective To investigate the relationship between red blood cell distribution width(RDW), neutrophil/lymphocyte ratio (NLR) and endothelial function in essential hypertensive patients. Methods We continuous enrolled 111 hypertensives patients from the Xuanwu hospital affiliated to Capital Medical University under the strict inclusion criteria. The Endo-PAT2000(Itamar Medical Inc.Caesarea) noninvasive testing equipment of vascular endothelial function measured reactive hyperemia index (RHI) which was used to evaluate vascular endothelial function and arterial stiffness in morning fasting adoption.Patients were divided into two groups:normal RHI group(RHI>1.67,n=63),abnormal RHI group (RHI ≤ 1.67,n=48).We also recorded age, blood pressure, history of smoking, fasting blood check. Results Systolic blood pressure (SBP) and pulse pressure (PP) in abnormal RHI group were significantly higher than those in normal RHI group.The Pearson correlation analysis indicated that, RHI was negatively associated with NLR(r=-0.358, P<0.01),SBP(r=-0.300, P=0.001)and PP(r=-0.311, P=0.001).Conclusion RHI gradually was declined with the elevation of NLR levels in hypertensives, and there was a linear correlation between them, which indicated that they may be associated with hyertensives endothelial injury. Further longitudinal studies are needed to better understand the causal relationship between endothelial function and NLR.

Key words: essential hypertension, red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), reactive hyperemia index (RHI)

CLC Number:

R544.1

Zhou Yaqun, Ding Cuntao, Sun Xipeng, Li Jing, Hua Qi. Relationship between RDW, neutrophil/lymphocyte ratio and endothelial function in essential hypertensive patients[J]. Journal of Capital Medical University, 2018, 39(2): 292-298.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.025

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/292

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