Primary investigation on clinical of Nuzhen decoction on diminished ovarian reserve in type of internal heat due to yin deficiency

doi:10.3969/j.issn.1006-7795.2019.03.007

Abstract

Abstract: Objective To observe the clinical effect of Nuzhen decoction on diminished ovarian reserve (DOR) belonged to the type of internal heat due to yin deficiency. Methods Totally 70 patients of DOR were randomly divided into two groups using EXCEL software. The treatment group was given Nuzhen decoction and the control group was treated with Kuntai capsule. Both groups started taking medicine on the fifth day of menstruation and stopped taking medicine on the first day of the next menstruation. The treatment lasted for three months for a course. The follow-up period was 6 months. All patients were evaluated at traditional Chinese medicine (TCM) syndrome evaluation, serum endocrine index follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), anti-Mullerian hormone (AMH), inhibin B (INHB),antral follicle count(AFC).Results For both groups the TCM syndromes were effectively improved and the scores of TCM syndromes were reduced. The levels of FSH and FSH/LH in serum on the 2 nd to 4 th day of menstruation were reduced and the levels of AMH in serum and AFC were increased. These changes in the treatment group were superior to that in the control group. Conclusion Nuzhen decoction can improve ovarian reserve function by improving ovarian responsiveness.

Key words: diminished ovarian reserve, internal heat due to yin deficiency, Nuzhen decoction

CLC Number:

R271

Yang Wei, Li Majian, He Junqin. Primary investigation on clinical of Nuzhen decoction on diminished ovarian reserve in type of internal heat due to yin deficiency[J]. Journal of Capital Medical University, 2019, 40(3): 358-362.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.03.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I3/358

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