Primary investigation on clinical effect of carbazochrome sodium sulfonate and sodium chloride injection on neurogenic pulmonary edema in severe cerebrovascular disease patients

doi:10.3969/j.issn.1006-7795.2020.03.027

Abstract

Abstract: Objective To observe the clinical effect of carbazochrome sodium sulfonate and sodium chloride injection on neurogenic pulmonary edema (NPE) in severe cerebrovascular disease patients. Methods Totally 40 patients of severe cerebrovascular disease complicated with NPE, in accordance with the random number table, were randomly divided into two groups and numbered according to the order of hospitalization. The treatment group was given carbazochrome sodium sulfonate injection and standard therapy. The control group was only given standard therapy. The clinical efficacy, hemodynamic index and inflammatory index before and after treatment (2^nd, 4^th and 8^th day) in the two groups were compared. Results The offline period, duration of antibiotics, duration of intensive care unit (ICU) stay, mortality and incidence of multiple organ dysfunction syndrome (MODS) of the treatment group were significantly lower than those of the control group (P<0.05). The extravascular lung water index (EVLWI) after treatment (4^th and 8^th day) of the treatment group were significantly lower than those of the control group (P<0.05). The pulmonary vascular permeability index (PVPI) after treatment (8^th day) of the treatment group were significantly lower than those of the control group (P<0.05). There was no significant difference in C-reactive protein (CRP), white blood cell (WBC) and neutrophil percent (NEUT%) before treatment between the two groups (P>0.05). CRP, WBC and NEUT% after treatment (2^nd, 4^th and 8^th day) of the treatment group were significantly lower than those of the control group (P<0.05). Conclusion The application of carbazochrome sodium sulfonate in the patients with severe cerebrovascular disease complicated with NPE is effective, which provides a new therapeutic strategy.

Key words: severe cerebrovascular disease, neurogenic pulmonary edema, carbazochrome sodium sulfonate, capillary permeability

CLC Number:

R743
R563

Lu Xiaojiong, Chen Feng, Wang Ying, Ma Jianxin, Zhao Sumin. Primary investigation on clinical effect of carbazochrome sodium sulfonate and sodium chloride injection on neurogenic pulmonary edema in severe cerebrovascular disease patients[J]. Journal of Capital Medical University, 2020, 41(3): 470-474.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.03.027

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I3/470

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