“Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei

doi:10.3969/j.issn.1006-7795.2020.05.012

Abstract

Abstract: The active natural products of traditional Chinese medicine are not only the active molecules that exert clinical curative effects, but also the source of developing modern innovative medicines. Professor Gao Wei's laboratory dedicates in cloning and identifying key enzymes in the biosynthetic pathway of active natural products, analyzing their biosynthetic pathways and applying synthetic biology methods to construct cell factories to produce or modify the active natural products. The promising research strategy and innovative production model have important scientific value for reducing dependence on natural resources, protecting natural environment and achieving large-scale production.

Key words: bio-active natural products of traditional Chinese medicine, key enzymes, biosynthetic pathway, synthetic biology, production, evaluation of pharmacological activity

CLC Number:

Tong Yuru, Zhang Yifeng, Shen Siyu, Gao Wei. “Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei[J]. Journal of Capital Medical University, 2020, 41(5): 783-787.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.05.012

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I5/783

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