Characteristics of myocardial metabolism on PET/CT in patients with newly diagnosed lung adenocarcinoma and factors associated with high left ventricular metabolism

doi:10.3969/j.issn.1006-7795.2021.01.001

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (1): 1-7.doi: 10.3969/j.issn.1006-7795.2021.01.001

• Basic and Clinical Research in Nuclear Medicine • Next Articles

Characteristics of myocardial metabolism on PET/CT in patients with newly diagnosed lung adenocarcinoma and factors associated with high left ventricular metabolism

Wang Li¹, Wu Jiaoyan², Yang Minfu^2*

1. Department of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;
2. Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2020-11-30 Online:2021-02-21 Published:2021-02-02
Contact: ^*E-mail:minfuyang@126.com
Supported by:
National Natural Science Foundation of China (81801739), Natural Science Foundation of Beijing (7182059).

Abstract

Abstract: Objective To explore whether myocardial glucose metabolism is altered and its related factors in newly diagnosed patients with lung adenocarcinoma (LAD) who underwent fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT). Methods From our ¹⁸F-FDG PET/CT imaging database, 182 patients with newly diagnosed LAD and 45 non-oncologic subjects with matched age and sex were retrospectively analyzed. The uptake of ¹⁸F-FDG in left ventricular (LV) myocardium, arterial wall, epicardial adipose tissue (EAT), spleen, and bone marrow were compared between the two groups. Multiple Logistic regression analysis was used to identify significant factors related with the high uptake of ¹⁸F-FDG in left ventricle of LAD. Results LAD patients had higher uptake of ¹⁸F-FDG in left ventricle than that of non-oncologic patients (P=0.05), whereas no significant difference of ¹⁸F-FDG uptake was found in the arterial wall, EAT, spleen, or bone marrow between the two groups. The activity of EAT was independently related to the high LV ¹⁸F-FDG uptake in LAD before antineoplastic therapy. Conclusion Myocardial glucose metabolism was increased in patients with LAD before antineoplastic therapy. The activity of EAT was an independent factor for prediction of the high LV ¹⁸F-FDG uptake in LAD.

Key words: lung adenocarcinoma, myocardial metabolism, ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG), positron emission tomography/computed tomography(PET/CT)

CLC Number:

Wang Li, Wu Jiaoyan, Yang Minfu. Characteristics of myocardial metabolism on PET/CT in patients with newly diagnosed lung adenocarcinoma and factors associated with high left ventricular metabolism[J]. Journal of Capital Medical University, 2021, 42(1): 1-7.

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Characteristics of myocardial metabolism on PET/CT in patients with newly diagnosed lung adenocarcinoma and factors associated with high left ventricular metabolism

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