The value of 123I-MIBG SPECT/CT tomography imaging in Curie score of pediatric neuroblastoma

doi:10.3969/j.issn.1006-7795.2021.01.002

Abstract

Abstract: Objective To explore the value of ¹²³I-metaiodobenzylguanidine(¹²³I-MIBG ) plane imaging and single-photon emission computed tomography (SPECT)/ computed tomography (CT) in Curie score of pediatric neuroblastoma. Methods Retrospective analysis of ¹²³I-MIBG plane imaging and SPECT/CT tomography images of 211 pediatric neuroblastoma patients was performed. All patients were ranked into high-risk patients with stage 3 or 4. All scores of ¹²³I-MIBG SPECT/CT planar and tomography imaging were collected. Pathological results, other related imaging examinations and clinical follow-up results were used as gold standard of diagnosis. The differences between two imaging methods were compared, and also the diagnostic accuracy and consistency of two imaging methods were compared with gold standard of diagnosis. Results Based on planar imaging and SPECT/CT tomography, 48.82% (103/211) patients had same Curie scores while 51.18% (108/211) patients had different scores. Curie score of planar imaging and tomography were 0 (0,1) and 0 (0,2), respectively, with significant difference (Z=-3.46, P<0.001). According to the results of Curie score, patients were divided into high score group (≥2) and low score group (<2). There was significant difference between two imaging methods in grouping (P=0.001). The diagnostic accuracy rates of planar imaging and tomographic imaging were 51.66% and 93.84%, respectively, with significant difference (P＜0.001). The diagnostic consistency of two imaging with the gold standard of diagnosis was 0.44(0.34-0.54) and 0.90 (0.85-0.96) respectively. Compared with planar imaging, tomography imaging showed excellent consistency with gold standard of diagnosis. Conclusion Compared with planar imaging, tomography imaging had better diagnostic accuracy and consistency. The Curie score based on ¹²³I-MIBG SPECT/CT tomography imaging had an important significance for semi-quantitative evaluation of pediatric neuroblastoma.

Key words: iodine-123 metaiodobenzylguanidine, SPECT/CT, Curie score, neuroblastoma

CLC Number:

Wang Wei, Lu Xia, Liu Jun, Kan Ying, Liu Jie, Yang Jigang. The value of ¹²³I-MIBG SPECT/CT tomography imaging in Curie score of pediatric neuroblastoma[J]. Journal of Capital Medical University, 2021, 42(1): 8-14.

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The value of ¹²³I-MIBG SPECT/CT tomography imaging in Curie score of pediatric neuroblastoma

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